CAS No.: 1072833-77-2 | Ixazomib
Name: Ixazomib CAS No.: 1072833-77-2 MDL No.: MFCD18251438 MF: C14H19BCl2N2O4 MW: 361.03 MP: >142°C (subl.) Density: 1.306 Purity: 97% Min. Appearance: White to Pale Yellow solid
Categories：
Pharmaceutical Intermediates
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Product introduction
Name: Ixazomib
Synonyms:
(R)-(1-(2-(2,5-Dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid.
CAS No.: 1072833-77-2
MDL No.: MFCD18251438
MF: C14H19BCl2N2O4
MW: 361.03
MP: >142°C (subl.)
Density: 1.306
Purity: 97% Min.
Appearance: White to Pale Yellow solid
Application: A proteasome inhibitor
A potent and selective reversible proteasome inhibitor that inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 of 3.4 nM and a Ki of 0.93 nM.
Storage Condition: Inert atmosphere, Store in freezer, under -20°C.
Synthesis Route 1 (Yield 86.5%):
1201903-02-7 + 11113-50-1 -> 1072833-77-2
With hydrogen chloride In di-isopropyl ether at 20℃; for 5 h;
Synthesis Route 2 (Yield 76.5%):
1201903-02-7 -> 1072833-77-2
With hydrogen chloride; Dihydroxy-isobutyl-boran In methanol; hexane; water
Key words:
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